WASHINGTON (AP) — The Supreme Court is taking up two major Biden administration efforts to bump up the nation’s vaccination rate against COVID-19 at a time of spiking coronavirus cases because of the omicron variant.

The justices on the conservative-oriented court are hearing arguments Friday about whether to allow the administration to enforce a vaccine-or-testing requirement that applies to large employers and a separate vaccine mandate for most health care workers. The arguments were expected to last at least two hours.

Legal challenges to the policies from Republican-led states and business groups are in their early stages, but the outcome at the high court probably will determine the fate of vaccine requirements affecting more than 80 million people.

“I think effectively what is at stake is whether these mandates are going to go into effect at all,” said Sean Marotta, a Washington lawyer whose clients include the American Hospital Association. The trade group is not involved in the Supreme Court cases.

The challengers argue that the vaccine rules exceed the administration’s authority, but Solicitor General Elizabeth Prelogar, the administration’s top Supreme Court lawyer, wrote that both are needed to avoid unnecessary hospitalizations and deaths.

Keeping the vaccine mandate for health care workers on hold “will likely result in hundreds or thousands of deaths and serious illnesses from COVID-19 that could otherwise be prevented,” Prelogar wrote.

Nearly 207 million Americans, 62.3% of the population, are fully vaccinated, and more than a third of the country has received a booster shot, including the nine justices.

Andy Slavitt, a former adviser to the Biden administration on COVID-19, said the vaccine requirements are extremely effective for 15% to 20% of Americans “who don’t like to get a shot, but they will and don’t have any strenuous objection.”

The high court will weigh in on administration vaccine policies for the first time, although the justices have turned away pleas to block state-level mandates.

But a conservative majority concerned about federal overreach did bring an end to the federal moratorium on evictions put in place because of the pandemic.

Three conservatives, Chief Justice John Roberts and Justices Brett Kavanaugh and Amy Coney Barrett, probably hold the key to the outcome, Marotta said.

They broke with the other justices on the right over state mandates for health-care workers but joined them to allow evictions to resume.

Both vaccine rules will exacerbate labor shortages and be costly to businesses, opponents said. “People are going to quit. It will make a bad situation worse and they’re not going to come back,” said Karen Harned, executive director of the National Federation of Independent Business’ Small Business Legal Center.

Her group is among those challenging an emergency rule adopted by the Occupational Safety and Health Administration under which workers at businesses with 100 or more employees must be vaccinated or get tested weekly and wear masks while working. The rule has exceptions for those who work alone or mostly outdoors.

The OSHA rule is supposed to take effect Monday, although the agency has said it would not impose fines on businesses that don’t comply before late February.

The vaccine mandate, for its part, applies to virtually all health care staff in the country. It covers health care providers that receive federal Medicare or Medicaid funding, potentially affecting 76,000 health care facilities as well as home health care providers. The rule has medical and religious exemptions.

Decisions by federal appeals courts in New Orleans and St. Louis have blocked the mandate in about half the states. The administration has said it is taking steps to enforce it in the rest.

Both cases are coming to the court on an emergency basis and the court took the unusual step of scheduling arguments rather than just ruling on briefs submitted by the parties. Unlike in other cases, the court hears, a decision from the justices could come in weeks, if not days.

Because of the pandemic the justices will hear the cases in a courtroom closed to the public. Only the justices, lawyers involved in the cases, court staff and journalists will be present. The public can listen live, however, a change made earlier in the pandemic when the justices for nearly 19 months heard cases via telephone.