(NewsNation) — A new report by a pediatrician appointed by the National Health Service England raises concerns about medical gender treatments for minors, particularly when it comes to puberty blockers.

This news comes as a Health Review Board and England are now limiting medications because of a lack of evidence of their benefits as well as reservations about long-term health care.

The nearly 400-page report, authored by Dr. Hillary Cass, the former president of the Royal College of Pediatrics and Child Health, writes that thousands of vulnerable youth have been given life-altering medications and treatments.

However, “the reality is that we have no good evidence on the long-term outcomes of interventions to manage gender-related distress,” Cass wrote.

“It has been suggested that hormone treatment reduces the elevated risk of death by suicide in this population, but the evidence found did not support this conclusion,” she wrote.

This review was commissioned by England’s Health Service after whistleblowers at the Tavistock Gender Clinic outlined how kids were fast-tracked to medications despite the evidence. The Health Service closed Tavistock, its main gender clinic, citing the “scarce and inconclusive evidence to support clinical decision-making.”

Marcus Evans, a clinician and governor at that clinic, was one of those whistleblowers.

When asked about Cass’ report, he told NewsNation, “The first thing she says is the whole environment is being toxic and politicized.”

“That has interfered with people listening to whistleblowers like me, but it’s also interfered with her getting evidence for her report,” Evans said.

Evans said Cass aims a lot of criticism at what’s called the Affirmation Model.

“That model is based off the idea that someone comes in with a belief, and one should affirm what they’re saying,” Evans said. “This is completely antithetical to good mental health practice.”

Cass’ report challenges gender-affirming care at its core and the stance that major American medical groups have taken on the issue.

Jamie Reed, who identifies as a queer woman married to a trans man, blew the whistle on the Pediatric Gender Center at Washington University in St. Louis after working there.

The English report’s conclusion, Reed says, is critically important and should guide decisions in the United States.

“Puberty blockers are out. Puberty blockers are no longer to be used in pediatric or adolescent populations,” Reed said. “The scientific evidence does not support their use. Second, cross-sex hormones should be used on such a limited basis and only in extreme caution. I believe that we have now been given a direct framework from an amazing partner country who utilized their National Health System to do systematic reviews of evidence and they have given us a nonpartisan pathway forward a way to move forward in our country outside of the partisanship, utilizing the best scientific evidence that is currently available.”

NewsNation reached out to the American Medical Association, American Academy of Pediatrics and the U.S. Department of Health and Human Services for comment.