BEIRUT (AP) — Hamas leader Ismail Haniyeh was killed by a predawn airstrike in the Iranian capital Wednesday, Iran and the militant group said, blaming Israel for a shock assassination that risks escalating the conflict even as the U.S. and other nations were scrambling to prevent an all-out regional war. Iran’s supreme leader vowed revenge against Israel.

There was no immediate comment from Israel, which has pledged to kill Haniyeh and other Hamas leaders over the group’s Oct. 7 attack on southern Israel in which the Palestinian militant group killed 1,200 people and took some 250 others hostage. The strike came just after Haniyeh had attended the inauguration of Iran’s new president in Tehran — and only hours after Israel targeted a top commander in Iran’s ally Hezbollah in the Lebanese capital Beirut.

The dramatic assassination of Hamas’s top political leader threatened to reverberate throughout the region’s intertwined conflicts. Most explosively, the strike in Tehran could push Iran and Israel into direct conflict if Iran retaliates.

“We consider his revenge as our duty,” Iranian supreme leader Ayatollah Ali Khamenei said in a statement on his official website. He said Israel had “prepared a harsh punishment for itself” by killing “a dear guest in our home.”

Bitter regional rivals, Israel and Iran risked plunging into war earlier this year when Israel hit Iran’s embassy in Damascus in April. Iran retaliated and Israel countered in an unprecedented exchange of strikes on each other’s soil, but international efforts succeeded in containing that cycle before it spun out of control.

Haniyeh’s killing could also prompt Hamas to pull out of negotiations for a cease-fire and hostage release deal in the 10-month-old war in Gaza, which U.S. mediators had said were making progress.

And it could enflame already heightening tensions between Israel and Hezbollah — which international diplomats were trying to contain after a weekend rocket attack that killed 12 young people in the Israeli-controlled Golan Heights.

Tuesday evening, Israel carried out a rare strike in the Lebanese capital that it said killed a top Hezbollah commander allegedly behind the rocket strike. Hezbollah, which denied any role in the Golan strike, said Wednesday that it was still searching for the body of Fouad Shukur in the rubble of the building that was hit in a Beirut suburb, killing two women and two children, according to the Lebanese Health Ministry.

There was no immediate reaction from the White House to the killing of Haniyeh.

Asked by reporters in Manila about the Tehran strike, U.S. Secretary of Defense Lloyd Austin said he had no “additional information to provide.” But he expressed hope for a diplomatic solution on the Israeli-Lebanon border.

“I don’t think that war is inevitable,” he said. “I maintain that. I think there’s always room and opportunity for diplomacy, and I’d like to see parties pursue those opportunities.”

But international diplomats trying to defuse tensions were alarmed. One Western diplomat, whose country has worked to prevent an Israeli-Hezbollah escalation, said the double strikes in Beirut and Tehran have “almost killed” hopes for a Gaza cease-fire and could push the Middle East into a “devastating regional war.” The diplomat spoke on condition of anonymity to discuss the sensitive situation.

An Israeli military spokesman declined to comment. Israel often doesn’t comment on assassinations carried out by its Mossad intelligence agency or strikes on other countries.

Iranian media showed videos of Haniyeh and Iranian President Masoud Pezeshkian hugging after Pezeshkian’s inauguration ceremony Tuesday. Hours later, the strike hit a residence Haniyeh uses in Tehran, killing him, Hamas said in a statement.

It also quoted a past speech by Haniyeh in which he said the Palestinian cause has “costs” and “we are ready for these costs: martyrdom for the sake of Palestine, and for the sake of God Almighty, and for the sake of the dignity of this nation.”

Pezeshkian vowed his country would “defend its territory” and make the attackers “regret their cowardly action.” An influential Iranian parliamentary committee on national security and foreign policy was to hold an emergency meeting on the strike later Wednesday.

Hamas’ military wing said in a statement that Haniyeh’s assassination “takes the battle to new dimensions and will have major repercussions on the entire region.” It said Israel “made a miscalculation by expanding the circle of aggression.”

Speaking to the AP, a Hamas spokesman Sami Abu Zuhri said the loss of Haniyeh won’t impact the group, saying it had emerged stronger after past crises and assassinations of its leaders.

Haniyeh left the Gaza Strip in 2019 and had lived in exile in Qatar. The top Hamas leader in Gaza is Yehya Sinwar, who masterminded the Oct. 7 attack.

In the West Bank, the internationally backed Palestinian President Mahmoud Abbas condemned Haniyeh’s killing, calling it a “cowardly act and dangerous development.” Political factions in the occupied territory called for strikes in protest at the killing.

In April, an Israeli airstrike in Gaza killed three of Haniyeh’s sons and four of his grandchildren.

Meanwhile, Iraq’s Popular Mobilization Forces, a coalition of Iranian-backed militias, said that a strike Tuesday night on a base southwest of Baghdad killed four members of the Kataib Hezbollah militia.

The group accused the United States of being behind the strike. Kataib Hezbollah, along with some of the other militias, has in recent months carried out attacks against bases housing U.S. troops in Iraq and Syria in retaliation for Washington’s support for Israel in the war in Gaza. U.S. officials did not immediately comment.

Israel is suspected of running a yearslong assassination campaign targeting Iranian nuclear scientists and others associated with its atomic program. In 2020, a top Iranian military nuclear scientist, Mohsen Fakhrizadeh, was killed by a remote-controlled machine gun while traveling in a car outside Tehran.

In Israel’s war against Hamas since the October attack, more than 39,360 Palestinians have been killed and more than 90,900 wounded, according to the Gaza Health Ministry, whose count does not differentiate between civilians and combatants.

___

Associated Press writers Amir Vahdat in Tehran, Iran, David Rising in Bangkok, and Jon Gambrell in Ubud, Indonesia, contributed to this report.